Assessment of 2 commercial vaccines against (Piscirikettsia salmonis), causative agent of Salmon Rikettsial Syndrome (SRS), disease using a complete cohabitation challenge model in sea water.
Piscirickettsiosis, or salmonid rickettsial septicaemia (SRS), caused by Piscirickettsia salmonis, is one of the largets threats to Chilean aquaculture. Several vaccines are registered, but the disease situation is far from under control.
Objective: Assessment of 2 commercial vaccines within three different concentrations of one of them, both products indicated for SRS for the Chilean market will be evaluated, in order to observe a potential dose response against P. salmonis infection under a complete cohabitation challenge model.
There has no previous studies described the antigen dose responses in water-based vaccines against SRS. Therefore this trial has a high importance in both scientific and industrial manner. A 400 Atlantic salmon (Salmo salar) will be vaccinated and 80 fish will be infected with P. salmonis by intraperitoneal injection as shedders. A 200 vaccinated fish will be kept as back-up. A total of 680 Fish.
Fish will eventually experience discomfort during disease challenge due to disease symptoms. Fish beeing unable to swim, obviously lethargic will be remowed from the tanks, recorded as dead.
Objective: Assessment of 2 commercial vaccines within three different concentrations of one of them, both products indicated for SRS for the Chilean market will be evaluated, in order to observe a potential dose response against P. salmonis infection under a complete cohabitation challenge model.
There has no previous studies described the antigen dose responses in water-based vaccines against SRS. Therefore this trial has a high importance in both scientific and industrial manner. A 400 Atlantic salmon (Salmo salar) will be vaccinated and 80 fish will be infected with P. salmonis by intraperitoneal injection as shedders. A 200 vaccinated fish will be kept as back-up. A total of 680 Fish.
Fish will eventually experience discomfort during disease challenge due to disease symptoms. Fish beeing unable to swim, obviously lethargic will be remowed from the tanks, recorded as dead.