Therapy and Toxicity of a new Antibody Drug Conjugate
A new Antibody Drug Conjugate (ADC) for treatment of Leukemia is currently under development by Nordic Nanovector. A more targeted treatment using an antibody coupled with a toxin may be more beneficial for leukemia patients. The antibody will deliver the drug more specifically to the tumor cells to minimize side effects.
This study will examine the therapeutic potential of the ADC in mice bearing a human xenograft representative of the cancer it is designed to treat. It has not previously been tested in vivo, and the information on the ADCs ability to delay tumor growth and to prolong survival compared to controls, is essential to make a decision on whether or not to move forward into clinical trials with the drug. The ADC will be compared with a specific unconjugated antibody, an unspecific unconjugated antibody and the current standard therapy for leukemia treatment. We apply for 362 mice in total for the study. The mice will be given cancer cells intravenously, and may become sick due to tumor cell infiltration in internal organs. The scientists in the study will closely monitor the mice and record the animals’ health in a Health score sheet (see attachment). If a mouse reaches one of the defined end point it will be euthanized
This study will examine the therapeutic potential of the ADC in mice bearing a human xenograft representative of the cancer it is designed to treat. It has not previously been tested in vivo, and the information on the ADCs ability to delay tumor growth and to prolong survival compared to controls, is essential to make a decision on whether or not to move forward into clinical trials with the drug. The ADC will be compared with a specific unconjugated antibody, an unspecific unconjugated antibody and the current standard therapy for leukemia treatment. We apply for 362 mice in total for the study. The mice will be given cancer cells intravenously, and may become sick due to tumor cell infiltration in internal organs. The scientists in the study will closely monitor the mice and record the animals’ health in a Health score sheet (see attachment). If a mouse reaches one of the defined end point it will be euthanized