Breeding of the INS-GAS strain

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Purpose of the experiment: Keeping INS-GAS transgenic mouse strain

Expected distress for the animals: Minimal distress. Lifespan of INS-GAS mice is usually more than 2 years.

Expected scientific or societal benefit: Spontaneous gastric inflammation and tumor.

How many and what kind of animals to be used: 200 INS-GAS mice

How demands for replacement, reduction and improvement will be adhered to: No demands as this is a unique model that mimics gastric mucosa, hypertrophy, hyperplasia, dyspepsia and tumor in humans.