Immune response triggered by nanoparticles conjugated with Poly I:C in Atlantic salmon
Fish farming is hampered by infectious diseases caused by bacteria, viruses and parasites whose detrimental impact is facilitated by the high density of fish in aquaculture. The major aim of this project is to test if Poly I:C, in a nanoparticle formulation, is able to mount a strong immune response and if it can be used as a targeted antigen delivery system for Atlantic salmon. Nanoparticle-based vaccine formulations are predicted to
result in an increased efficiency and potency, and different materials can be used to target specific responses and tissues (1)
We want to identify transcriptional changes in immune response pattern and which transcripts are up or down regulated after injection of Poly I:C/nanoparticle formulation. Control groups will be injected either with PBS (saline), Poly I:C alone or with nanoparticle alone.
1. J.D. Smith, L.D. Morton, B.D. Ulery. Nanoparticles as synthetic vaccine. Curr Opin Biotechnol, 34 (2015), pp. 217–224.
result in an increased efficiency and potency, and different materials can be used to target specific responses and tissues (1)
We want to identify transcriptional changes in immune response pattern and which transcripts are up or down regulated after injection of Poly I:C/nanoparticle formulation. Control groups will be injected either with PBS (saline), Poly I:C alone or with nanoparticle alone.
1. J.D. Smith, L.D. Morton, B.D. Ulery. Nanoparticles as synthetic vaccine. Curr Opin Biotechnol, 34 (2015), pp. 217–224.