Test the safety of substances w, x y and z in Atlantic salmon (Salmo salar)
Parasite A causes serious losses to the Atlantic salmon farming industry and several methods have been employed (both physical and chemical) to reduce its effect on farmed salmon. At present there is a strong need for developing new active ingredients that can target parasite A but at the same time these substances should be safe for fish. Substances w, x, y and z are different forms of the same chemical class and will be tested for safety through a bath treatment trial in Atlantic salmon. As the safety of these chemicals in salmon is not established, the experiments will be classified as severe. If the test substances are proved to be safe to fish then they could be developed as highly efficacious active ingredients against parasite A in salmon.
A total of 140 Atlantic salmon parrs reared in fresh water will be used in the study. There are no alternatives to the safety testing of chemical substances on fish at present but the number of dose groups (and therefore fish numbers) has been optimized due to prior knowledge on invitro efficacy. The fish will be housed in a favourable light regime and water quality will be monitored. Humane endpoint will be implemented ie. fish showing distress, unable to swim and lying on the back, showing abnormal behaviour etc. will be caught and euthanized using an anesthetic overdose.
A total of 140 Atlantic salmon parrs reared in fresh water will be used in the study. There are no alternatives to the safety testing of chemical substances on fish at present but the number of dose groups (and therefore fish numbers) has been optimized due to prior knowledge on invitro efficacy. The fish will be housed in a favourable light regime and water quality will be monitored. Humane endpoint will be implemented ie. fish showing distress, unable to swim and lying on the back, showing abnormal behaviour etc. will be caught and euthanized using an anesthetic overdose.
Etterevaluering
Betydelig belastende
Begrunnelse for etterevalueringen
Forsøkets formål var å undersøke sikkerheten for laks ved bruk av 4 kjemiske substanser mot en parasitt. Stoffene w, x, y, og z er ulike former av en felles kjemisk klasse, og det forsøket undersøkte sikkerheten for laks når disse stoffene brukes i en badebehandling.
Søker angir at forsøk gjennomført iht protokoll. Substansene hadde ingen negativ effekt på fisken.
Totalt 140 atlantisk laks ble brukt. For alle disse var vurderes belastningen til å være mild.
Søker angir at å gjennomføre forsøket i større tank kunne gitt ett bedre miljø for fisken. Siden substansene ble funnet trygge til bruk kan dette i seg selv bidra til bedre fiskevelferd i fremtiden.
Søker angir at forsøk gjennomført iht protokoll. Substansene hadde ingen negativ effekt på fisken.
Totalt 140 atlantisk laks ble brukt. For alle disse var vurderes belastningen til å være mild.
Søker angir at å gjennomføre forsøket i større tank kunne gitt ett bedre miljø for fisken. Siden substansene ble funnet trygge til bruk kan dette i seg selv bidra til bedre fiskevelferd i fremtiden.